Page 23 - Škrgat, Sabina, ed. 2022. Severe Asthma - Basic and Clinical Views. Koper: University of Primorska Press. Severe Asthma Forum, 1

clusion
For many years, severe asthma has been rec-
ognized as a subset of asthma that is poor- 7.
ly managed by standard therapy for asthma.
Nowadays asthma is considered an umbrel-
la diagnosis for several diseases with variable
clinical presentations (phenotypes) and dis- 8.
tinct mechanistic pathways (endotype). The
precise definition of these endotypes and de-
ciphering the complex interplay of several in-
dividual pathways and immune cells is cen- 9.
tral to asthma management due to inherent
biological therapeutic implications. The iden-
tification and understanding of the molecular
mechanisms of different asthma endotypes,
that reflect a highly variable response to dif- 10.
ferent treatments, will lead to more precise
asthma management and better outcomes in
patients.
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